ST JOHNS WORT 0.3% is obtained from the plant Hypericum perforatum which gives significant effect against depression with lesser side effects. It also acts in wound healing by enhancing collagen production. Moreover, it reduces opium dependence and exhibits antimicrobial as well as antiviral activities. It contains a compound naming ëhyperforiní which has significant inhibitory action against gram-positive bacteria and both methicillin and penicillin resistant Staphylococcus aureus were susceptible to it. It contains catechins and flavonoids which work against influenza virus. It has 3-hydroxy lauric acid which has potential anti-HIV activity and also has hypericin which inactivated the bovine diarrhea virus completely.