BUPLEURUM EXTRACT 10-1 is obtained from Bupleurum chinense which has a wide range of therapeutic activities including analgesic, antipyretic, immunomodulatory, antiviral, hepatoprotective, sedative, anticancer and antihyperlipidemic . These diversified activities are due to the presence of saikosaponin-a, saikosaponin-c and saikosaponin-d. Saikosaponin-a is responsible for antioxidative, anti-inflammatory, antiproliferative, hepatoprotective activities. Saikosaponin-c exhibits capillary vascularization, anti-hepatitis, activities. Saikosaponin-d influences autophagy and in apoptosis, induces autophagic cell death.